GRM8

Across TCGA patient cohorts, GRM8 protein abundance is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GRM8-associated genes across cancer lineages are GSKIP, TPD52L2, and ARFGAP1. Each is linked with GRM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRM8-to-partner and partner-to-GRM8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRM8 versus GSKIP in GBM, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM8→partner) and Y-score (partner→GRM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GSKIP →	+0.514	+0.861	<.001	<.001	3	1
GBM	TPD52L2 →	-0.364	-0.727	.004	.002	3	1
GBM	ARFGAP1 →	-0.494	-0.656	.004	.007	3	1
GBM	HM13 →	-0.455	-0.702	.004	.003	3	1
GBM	TM9SF4 →	-0.413	-0.821	.003	<.001	3	1
GBM	PGRMC1 →	+0.944	+1.071	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

GRM8 vs GSKIP — GBM

Explore this scatter interactively →