GRM8

Across TCGA pan-cancer cohorts, GRM8 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GRM8 data layer compared with 11 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GRM8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRM8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

UVM, KIRC, and OV are the cancer types where GRM8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.386	0.760	<.001	134	view →
KIRC	DFS	Median	III,IV	0.566	0.374	.003	73	view →
OV	OS	Quartile	All	0.892	0.782	.003	50	view →
BLCA	OS	Quartile	III,IV	0.556	0.731	.002	47	view →
LUAD	DFS	Tertile	III,IV	0.754	0.238	<.001	34	view →
HNSC	DFS	Tertile	All	0.767	0.633	.002	26	view →
LIHC	OS	Median	All	0.410	0.614	<.001	25	view →
UCEC	DFS	Tertile	IV	0.607	0.237	.012	24	view →
MESO	OS	Median	All	0.724	0.298	.008	24	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →
COAD	OS	Tertile	III,IV	0.812	0.545	.010	12	view →
ACC	DFS	Median	IV	0.472	0.089	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GRM8–UVM (DFS)

Open the UVM breakdown →