GRM8

Across TCGA patient cohorts, GRM8 mutation is significantly associated with the RNA expression of many other genes, with 6,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM8-associated genes across cancer lineages are NPM3, CDKN3, and OIP5. Each is linked with GRM8 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRM8-to-partner and partner-to-GRM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPM3 grouped by GRM8-low versus GRM8-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM8→partner) and Y-score (partner→GRM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NPM3 →	+0.696	+2.857	.003	.001	3	5
UCEC	CDKN3 →	+0.688	+1.836	<.001	<.001	3	5
UCEC	OIP5 →	+0.682	+1.530	<.001	<.001	3	5
UCEC	FOXM1 →	+0.565	+1.384	.002	<.001	3	5
UCEC	DYNC2I2 →	+0.374	+2.145	.002	<.001	3	5
UCEC	KIF18A →	+0.513	+1.519	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,624 associations by consensus.

NPM3 by GRM8 expression — STAD

Explore this box plot interactively →