GRM8

Across TCGA patient cohorts, GRM8 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM8-associated genes across cancer lineages are ACC1, C-Raf, and Caspase-7-cleavedD198. Each is linked with GRM8 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM8-to-partner and partner-to-GRM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by GRM8-low versus GRM8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM8→partner) and Y-score (partner→GRM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACC1 →	+0.433	+3.000	.034	.035	3	4
UCEC	C-Raf →	+0.127	+1.716	.001	.003	3	4
UCEC	Caspase-7-cleavedD198 →	+0.425	+2.019	.007	<.001	3	4
UCEC	Cyclin-B1 →	+0.626	+1.807	<.001	<.001	3	4
LUAD	p70-S6K →	+0.172	+1.765	.013	.012	3	3
COAD	Cyclin-E1 →	+0.317	+2.008	.001	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

ACC1 by GRM8 expression — HNSC

Explore this box plot interactively →