GRM8

Across TCGA cell cohorts, GRM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,428 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GRM8-associated GO terms across cancer lineages are Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, snRNA modification, and Positive regulation of leukocyte apoptotic process. Each is linked with GRM8 in more than 7 cancer types. Because this analysis shows association rather than direction, both GRM8-to-partner and partner-to-GRM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway grouped by GRM8-low versus GRM8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM8→partner) and Y-score (partner→GRM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway →	+1.755	+1.984	<.001	<.001	3	8
SKIN	snRNA modification →	+0.074	+0.731	<.001	.003	3	6
BONE	Positive regulation of leukocyte apoptotic process →	-0.093	-1.349	.005	.007	3	6
LUNG_SCLC	Regulation of chromosome organization →	+0.067	+1.965	<.001	.004	3	6
LUNG_SCLC	Positive regulation of DNA repair →	+0.067	+2.132	<.001	.001	3	6
BONE	Nucleosome assembly →	+0.105	+1.727	.007	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,428 associations by consensus.

Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway by GRM8 expression — BONE

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