GRM8

Across TCGA cell cohorts, GRM8 mutation is significantly associated with the RNA expression of many other genes, with 688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM8-associated genes across cancer lineages are CLEC19A, SLC25A17, and TRMU. Each is linked with GRM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRM8-to-partner and partner-to-GRM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC19A grouped by GRM8-low versus GRM8-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM8→partner) and Y-score (partner→GRM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLEC19A →	+0.133	+4.807	<.001	.006	3	2
LARGE_INTESTINE	SLC25A17 →	+0.602	+3.459	<.001	.001	3	2
LARGE_INTESTINE	TRMU →	+0.525	+3.321	.002	.002	3	2
LARGE_INTESTINE	DTWD1 →	+0.459	+2.265	.009	.001	3	2
LARGE_INTESTINE	GSR →	+0.706	+2.949	.003	<.001	3	2
LARGE_INTESTINE	ASF1B →	+0.786	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 688 associations by consensus.

CLEC19A by GRM8 expression — BLOOD_Myeloma

Explore this box plot interactively →