Across TCGA cell cohorts, GRM7 mutation is significantly associated with the RNA expression of many other genes, with 754 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM7-associated genes across cancer lineages are KRTAP16-1, KRTAP5-6, and GPR148. Each is linked with GRM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRM7-to-partner and partner-to-GRM7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM7→partner) and Y-score (partner→GRM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP16-1 →	+0.010	+2.560	.002	.008	3	2
OVARY	KRTAP5-6 →	+0.171	+4.285	<.001	<.001	3	2
CNS	GPR148 →	+0.007	+3.772	<.001	.008	3	2
LARGE_INTESTINE	PAIP2B →	+0.641	+2.743	.004	.001	3	2
LARGE_INTESTINE	WRAP53 →	+0.525	+2.043	.002	.008	3	2
LARGE_INTESTINE	ATP5F1A →	+0.829	+3.404	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 754 associations by consensus.

Exploration

GRM7 survival (RNA) · tumor vs normal (RNA) · all GRM7 data types