GRM5-AS1

Across TCGA pan-cancer cohorts, GRM5-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GRM5-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GRM5-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GRM5-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, COAD, and BRCA are the cancer types where GRM5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.889	0.724	<.001	54	view →
COAD	DFS	Tertile	II,III,IV	0.291	0.669	<.001	54	view →
BRCA	DFS	Quartile	All	0.940	0.891	.009	50	view →
LIHC	OS	Tertile	II,III,IV	0.346	0.681	<.001	42	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	36	view →
UCS	DFS	Quartile	II,III,IV	0.661	0.106	.001	30	view →
THCA	DFS	Quartile	IV	0.218	0.873	<.001	29	view →
CESC	DFS	Tertile	III,IV	0.850	0.644	.036	12	view →
TGCT	DFS	Quartile	All	0.451	0.712	.014	10	view →
SKCM	OS	Tertile	IV	0.167	0.657	.003	9	view →
CHOL	DFS	Median	All	0.674	0.133	.007	9	view →
KIRP	DFS	Tertile	All	0.941	0.839	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GRM5-AS1–KIRC (DFS)

Open the KIRC breakdown →