GRM5-AS1

Across TCGA pan-cancer cohorts, GRM5-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GRM5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GRM5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRM5-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, THCA, and KICH are the cancer types where GRM5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRM5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.100	<.001	10	view →
THCA	Male	All	+0.021	<.001	8	view →
KICH	All	III,IV	−0.085	<.001	6	view →
KIRC	All	All	+0.064	<.001	6	view →
HNSC	All	All	+0.015	.010	5	view →
UCEC	All	All	+0.022	.035	4	view →
LUSC	All	All	+0.093	.007	3	view →
KIRP	All	All	+0.294	.003	2	view →
CHOL	All	All	+0.432	.010	1	view →
LIHC	Female	All	+0.009	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GRM5-AS1–LUAD

Open the LUAD breakdown →