GRM3-AS1

Across TCGA pan-cancer cohorts, GRM3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GRM3-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GRM3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRM3-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and ACC show a favorable association.

HNSC, MESO, and READ are the cancer types where GRM3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.255	0.581	<.001	55	view →
MESO	OS	Median	IV	0.838	0.313	.001	37	view →
READ	DFS	Tertile	III,IV	0.232	0.656	.002	36	view →
ACC	OS	Median	All	0.941	0.386	<.001	29	view →
BRCA	DFS	Tertile	III,IV	0.950	0.810	.003	28	view →
KIRC	DFS	Median	II,III,IV	0.408	0.612	.002	28	view →
PAAD	DFS	Tertile	All	0.423	0.207	.001	25	view →
BLCA	OS	Quartile	All	0.792	0.656	.010	24	view →
LUSC	DFS	Quartile	All	0.270	0.466	.003	24	view →
COAD	OS	Quartile	All	0.800	0.889	.013	13	view →
LIHC	DFS	Quartile	II,III,IV	0.541	0.154	.028	12	view →
GBM	DFS	Tertile	All	0.329	0.203	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GRM3-AS1–HNSC (DFS)

Open the HNSC breakdown →