GRM3-AS1

Across TCGA pan-cancer cohorts, GRM3-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GRM3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GRM3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GRM3-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, KIRC, and KICH are the cancer types where GRM3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRM3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.183	<.001	4	view →
KIRC	All	All	+0.072	.004	3	view →
KICH	All	All	+0.278	.013	2	view →
LUSC	Male	II,III,IV	−0.246	.002	2	view →
PAAD	All	All	−0.167	.040	2	view →
PRAD	All	All	+0.113	.015	2	view →
CHOL	All	All	+0.207	.027	1	view →
HNSC	All	IV	+0.068	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GRM3-AS1–LUAD

Open the LUAD breakdown →