GRM1

Across TCGA patient cohorts, GRM1 mutation is significantly associated with the RNA expression of many other genes, with 7,200 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM1-associated genes across cancer lineages are FCER1A, CORO2B, and GCAT. Each is linked with GRM1 in more than 6 cancer types. Because this analysis shows association rather than direction, both GRM1-to-partner and partner-to-GRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by GRM1-low versus GRM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM1→partner) and Y-score (partner→GRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FCER1A →	-0.878	-1.573	.007	.005	3	7
SKCM	CORO2B →	-1.371	-2.150	<.001	.003	3	6
UCEC	GCAT →	+0.430	+2.135	<.001	<.001	3	6
UCEC	BUB3 →	+0.422	+2.267	<.001	<.001	3	6
UCEC	DHFR →	+0.619	+1.436	<.001	<.001	3	6
STAD	LBH →	-0.775	-2.120	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,200 associations by consensus.

FCER1A by GRM1 expression — LUAD

Explore this box plot interactively →