GRM1

Across TCGA pan-cancer cohorts, GRM1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GRM1 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GRM1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

COAD, LUAD, and HNSC are the cancer types where GRM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.329	0.635	<.001	70	view →
LUAD	OS	Quartile	All	0.764	0.902	.002	50	view →
HNSC	DFS	Median	IV	0.677	0.494	.002	44	view →
PAAD	DFS	Median	All	0.526	0.243	<.001	43	view →
KIRC	DFS	Quartile	All	0.910	0.815	.003	30	view →
READ	OS	Median	IV	0.484	0.861	.004	27	view →
THCA	OS	Median	All	0.961	1.000	.002	25	view →
LGG	DFS	Tertile	All	0.890	0.770	<.001	25	view →
STAD	DFS	Quartile	II,III,IV	0.495	0.858	.001	24	view →
BLCA	DFS	Quartile	II,III,IV	0.431	0.559	.014	22	view →
ACC	OS	Quartile	III,IV	0.301	0.918	.024	21	view →
MESO	OS	Median	III,IV	0.533	0.296	.003	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GRM1–COAD (DFS)

Open the COAD breakdown →