GRM1

Across TCGA patient cohorts, GRM1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM1-associated genes across cancer lineages are cIAP, EGFR_pY1068, and AR. Each is linked with GRM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM1-to-partner and partner-to-GRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by GRM1-low versus GRM1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM1→partner) and Y-score (partner→GRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	cIAP →	+0.105	+1.857	.010	.004	3	4
COAD	EGFR_pY1068 →	-0.243	-1.861	.041	.049	3	4
STAD	AR →	-0.120	-2.279	.005	.005	3	3
STAD	Bap1-c-4 →	+0.332	+2.321	.014	.005	3	3
STAD	4E-BP1 →	+0.316	+2.459	.004	.018	3	3
UCEC	Cyclin-B1 →	+0.587	+1.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

cIAP by GRM1 expression — LUSC

Explore this box plot interactively →