GRM1

Across TCGA cell cohorts, GRM1 mutation is significantly associated with the RNA expression of many other genes, with 1,735 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM1-associated genes across cancer lineages are UFSP2, PPP1R3D, and RTCA. Each is linked with GRM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM1-to-partner and partner-to-GRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFSP2 grouped by GRM1-low versus GRM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM1→partner) and Y-score (partner→GRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UFSP2 →	+0.581	+2.614	<.001	.003	3	3
LARGE_INTESTINE	PPP1R3D →	-0.638	-3.118	<.001	<.001	3	3
LARGE_INTESTINE	RTCA →	+0.401	+1.537	.005	.007	3	3
BLOOD_Leukemia	FAM227B →	+0.683	+3.115	<.001	.009	2	4
LARGE_INTESTINE	C3orf33 →	+0.586	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	HMGN4 →	+0.464	+3.404	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,735 associations by consensus.

UFSP2 by GRM1 expression — BLOOD_Leukemia

Explore this box plot interactively →