Across TCGA pan-cancer cohorts, GRK5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRK5 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRK5 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where GRK5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.826	.005	36	view →
HNSC	DFS	Median	All	0.272	0.630	.011	12	view →
LUAD	OS	Median	All	0.318	0.700	.011	8	view →
COAD	OS	Median	II,III,IV	0.732	0.854	.041	5	view →
LUSC	DFS	Median	All	0.136	0.791	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GRK5 tumor-vs-normal RNA expression · all GRK5 data types