Across TCGA pan-cancer cohorts, GRK5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRK5’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GRK5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRK5 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.
KIRC, BLCA, and HNSC are the cancer types where GRK5 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRK5 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.