Across TCGA pan-cancer cohorts, GRK5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRK5 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GRK5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GRK5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where GRK5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.862	0.400	<.001	81	view →
LSCC	OS	Median	All	0.936	1.000	.011	9	view →
UCEC	OS	Tertile	II,III,IV	0.553	1.000	.016	8	view →
LUAD	DFS	Tertile	All	1.000	0.852	.023	2	view →
HNSC	DFS	Median	All	0.935	0.991	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GRK5 tumor-vs-normal RNA expression · all GRK5 data types