Across TCGA cell cohorts, GRK5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK5-associated genes across cancer lineages are LRRC53, LALBA, and PRAMEF7. Each is linked with GRK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK5-to-partner and partner-to-GRK5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK5→partner) and Y-score (partner→GRK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC53 →	+0.019	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LALBA →	+0.038	+4.922	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.029	+5.539	<.001	.003	3	1
LARGE_INTESTINE	NLRP2B →	+0.128	+4.139	<.001	.007	3	1
LARGE_INTESTINE	SCN11A →	+0.155	+3.772	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

GRK5 survival (RNA) · tumor vs normal (RNA) · all GRK5 data types