GRK4

Across TCGA patient cohorts, GRK4 mutation is significantly associated with the RNA expression of many other genes, with 2,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK4-associated genes across cancer lineages are RN7SL557P, GRAMD4P1, and GOT1. Each is linked with GRK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRK4-to-partner and partner-to-GRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL557P grouped by GRK4-low versus GRK4-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK4→partner) and Y-score (partner→GRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RN7SL557P →	+0.225	+5.846	<.001	.003	3	3
LUSC	GRAMD4P1 →	+0.040	+4.733	<.001	.004	3	3
UCEC	GOT1 →	+0.359	+2.134	.005	<.001	3	3
UCEC	WRAP53 →	+0.415	+2.091	.002	.001	3	3
SKCM	E2F7 →	+1.099	+3.385	<.001	.004	3	2
SKCM	PPP3R2 →	+0.036	+3.206	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,566 associations by consensus.

RN7SL557P by GRK4 expression — LGG

Explore this box plot interactively →