GRK4

Across TCGA pan-cancer cohorts, GRK4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GRK4 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher GRK4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRK4 expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

KICH, MESO, and UVM are the cancer types where GRK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.240	1.000	.001	75	view →
MESO	OS	Tertile	II,III,IV	0.209	0.503	.001	44	view →
UVM	DFS	Quartile	III,IV	0.179	0.811	.001	43	view →
ACC	OS	Quartile	All	0.308	0.956	<.001	33	view →
KIRP	DFS	Median	IV	0.039	0.594	.006	25	view →
UCS	OS	Tertile	IV	0.132	0.616	.038	24	view →
ESCA	OS	Tertile	All	1.000	0.491	.014	21	view →
KIRC	DFS	Quartile	III,IV	0.599	0.819	.007	19	view →
BRCA	DFS	Median	All	0.451	0.576	.001	16	view →
LUSC	DFS	Quartile	II,III,IV	0.353	0.683	.017	16	view →
LIHC	OS	Quartile	All	0.705	0.885	.005	14	view →
SARC	DFS	Quartile	All	0.208	0.576	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GRK4–KICH (DFS)

Open the KICH breakdown →