GRK4

Across TCGA cell cohorts, GRK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,560 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK4-associated GO terms across cancer lineages are Regulation of autophagy of mitochondrion, Regulation of mitophagy, and Regulation of macroautophagy. Each is linked with GRK4 in more than 12 cancer types. Because this analysis shows association rather than direction, both GRK4-to-partner and partner-to-GRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of autophagy of mitochondrion grouped by GRK4-low versus GRK4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK4→partner) and Y-score (partner→GRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of autophagy of mitochondrion →	+0.084	+0.934	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of mitophagy →	+0.092	+1.010	<.001	<.001	3	12
OESOPHAGUS	Regulation of macroautophagy →	+0.082	+0.857	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of aggrephagy →	+0.151	+0.683	<.001	<.001	3	12
OESOPHAGUS	Regulation of organelle assembly →	+0.047	+0.777	.003	.004	3	12
KIDNEY	Autophagosome organization →	+0.055	+0.877	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,560 associations by consensus.

Regulation of autophagy of mitochondrion by GRK4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →