GRK4

Across TCGA cell cohorts, GRK4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GRK4-associated genes across cancer lineages are OR2A5, H3C11, and CD1B. Each is linked with GRK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK4-to-partner and partner-to-GRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A5 grouped by GRK4-low versus GRK4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK4→partner) and Y-score (partner→GRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2A5 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	H3C11 →	+0.416	+4.807	<.001	.006	3	1
LUNG_SCLC	CD1B →	+0.360	+4.523	<.001	.003	3	1
LUNG_SCLC	LALBA →	+0.077	+4.269	<.001	.005	3	1
LUNG_SCLC	ACER1 →	+0.080	+4.044	<.001	.009	3	1
LUNG_SCLC	OR10K2 →	+0.020	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR2A5 by GRK4 expression — BLOOD_Myeloma

Explore this box plot interactively →