GRK3

Across TCGA pan-cancer cohorts, GRK3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRK3 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRK3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRK3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, HNSC, and STAD are the cancer types where GRK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.622	.003	36	view →
HNSC	DFS	Median	II,III,IV	0.122	0.695	.002	18	view →
STAD	DFS	Median	III,IV	1.000	0.332	.032	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GRK3–UCEC (DFS)

Open the UCEC breakdown →