Across TCGA cell cohorts, GRK1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GRK1-associated genes across cancer lineages are FBXO40, OR4D5, and MROH2B. Each is linked with GRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK1-to-partner and partner-to-GRK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK1→partner) and Y-score (partner→GRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FBXO40 →	+0.005	+4.189	.004	.002	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	MROH2B →	+0.488	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPATA8 →	+0.079	+3.977	.005	.005	3	1
LUNG_NSCLC_LUAD	MAGEB5 →	+0.030	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

GRK1 survival (RNA) · tumor vs normal (RNA) · all GRK1 data types