GRIP1

Across TCGA pan-cancer cohorts, GRIP1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated GRIP1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher GRIP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRIP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, LUAD, and SARC are the cancer types where GRIP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LUAD	OS	Median	III,IV	0.082	0.676	<.001	38	view →
SARC	DFS	Median	All	0.094	0.611	.001	9	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
LIHC	DFS	Median	II,III,IV	0.089	0.429	.005	6	view →
UCEC	DFS	Median	All	0.911	0.624	.026	4	view →
SKCM	OS	Median	All	0.633	0.294	.011	4	view →
COAD	DFS	Median	All	1.000	0.671	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

GRIP1–THYM (OS)

Open the THYM breakdown →