GRINA

Across TCGA patient cohorts, GRINA mutation is significantly associated with the RNA expression of many other genes, with 1,805 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRINA-associated genes across cancer lineages are PTP4A1P7, RN7SL163P, and MIR6507. Each is linked with GRINA in more than 1 cancer types. Because this analysis shows association rather than direction, both GRINA-to-partner and partner-to-GRINA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTP4A1P7 grouped by GRINA-low versus GRINA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRINA→partner) and Y-score (partner→GRINA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTP4A1P7 →	+0.176	+2.201	<.001	.004	3	2
UCEC	RN7SL163P →	+0.168	+2.179	<.001	.007	3	2
BRCA	MIR6507 →	+0.359	+8.055	<.001	.007	3	1
UCEC	INCENP →	+0.677	+2.743	.008	.003	3	1
UCEC	CPSF7 →	+0.514	+3.354	<.001	.005	3	1
UCEC	NOCT →	+0.699	+3.332	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,805 associations by consensus.

PTP4A1P7 by GRINA expression — UCEC

Explore this box plot interactively →