GRIN2D

Across TCGA pan-cancer cohorts, GRIN2D Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRIN2D data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GRIN2D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRIN2D expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, SARC, and KICH are the cancer types where GRIN2D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	III,IV	0.859	0.264	.004	39	view →
SARC	DFS	Median	All	0.067	0.613	<.001	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUAD	OS	Median	III,IV	0.228	0.677	.015	6	view →
UCEC	DFS	Median	All	0.926	0.619	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GRIN2D–BLCA (DFS)

Open the BLCA breakdown →