GRIN2D

Across TCGA pan-cancer cohorts, GRIN2D RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GRIN2D’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GRIN2D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRIN2D is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where GRIN2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIN2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+4.450	<.001	12	view →
HNSC	Female	IV	+2.911	<.001	12	view →
BLCA	All	III,IV	+1.759	<.001	11	view →
LUAD	All	III,IV	+1.386	<.001	11	view →
KIRC	Male	IV	+0.856	<.001	11	view →
STAD	Female	All	+3.578	<.001	10	view →
KIRP	Male	All	+0.643	<.001	9	view →
UCEC	All	All	+2.298	<.001	8	view →
BRCA	All	III,IV	+1.102	<.001	8	view →
THCA	Male	All	−0.642	<.001	8	view →
READ	Female	All	+4.242	<.001	7	view →
LUSC	All	II,III,IV	+1.771	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GRIN2D–COAD

Open the COAD breakdown →