GRIN2D

Across TCGA patient cohorts, GRIN2D mutation is significantly associated with the RNA expression of many other genes, with 3,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2D-associated genes across cancer lineages are RNU2-61P, POLR2KP2, and SUPT4H1P1. Each is linked with GRIN2D in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN2D-to-partner and partner-to-GRIN2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-61P grouped by GRIN2D-low versus GRIN2D-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2D→partner) and Y-score (partner→GRIN2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU2-61P →	+0.137	+5.035	<.001	.002	3	3
HNSC	POLR2KP2 →	+0.092	+4.286	<.001	.007	3	3
BLCA	SUPT4H1P1 →	+0.290	+2.732	<.001	.009	3	3
SKCM	HYKK →	+0.424	+3.208	.005	.009	3	3
HNSC	RNA5SP106 →	+0.149	+4.146	<.001	.008	3	3
UCEC	RNA5SP415 →	+0.353	+1.711	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,215 associations by consensus.

RNU2-61P by GRIN2D expression — HNSC

Explore this box plot interactively →