GRIN2D

Across TCGA patient cohorts, GRIN2D mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2D-associated genes across cancer lineages are MEK1, AMPK_pT172, and Annexin-1. Each is linked with GRIN2D in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN2D-to-partner and partner-to-GRIN2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GRIN2D-low versus GRIN2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2D→partner) and Y-score (partner→GRIN2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.303	+1.847	.015	.007	3	3
UCEC	AMPK_pT172 →	+0.358	+1.906	.010	.015	3	2
UCEC	Annexin-1 →	+0.729	+3.906	<.001	<.001	3	2
UCEC	ATM →	-0.459	-2.137	.002	.001	3	2
UCEC	Chk2 →	-0.185	-1.514	.020	.015	3	2
SKCM	JNK2 →	+0.250	+2.824	.044	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by GRIN2D expression — UCEC

Explore this box plot interactively →