GRIN2D

Across TCGA cell cohorts, GRIN2D mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN2D-associated genes across cancer lineages are PRAMEF12, HCG22, and TRIM64B. Each is linked with GRIN2D in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN2D-to-partner and partner-to-GRIN2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by GRIN2D-low versus GRIN2D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2D→partner) and Y-score (partner→GRIN2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF12 →	+0.034	+2.977	.006	.006	3	2
LARGE_INTESTINE	HCG22 →	+0.056	+2.444	<.001	.008	3	2
BREAST	TRIM64B →	+0.119	+3.672	<.001	.006	3	2
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	2
LUNG_NSCLC_LUAD	IL17A →	+0.002	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	CNPY1 →	+0.224	+3.189	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PRAMEF12 by GRIN2D expression — LARGE_INTESTINE

Explore this box plot interactively →