GRIN2C

Across TCGA pan-cancer cohorts, GRIN2C Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated GRIN2C data layer compared with 24 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GRIN2C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRIN2C expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

ACC, LUAD, and HNSC are the cancer types where GRIN2C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.068	0.674	<.001	31	view →
LUAD	OS	Median	All	0.265	0.837	<.001	31	view →
HNSC	OS	Median	III,IV	0.182	0.628	.017	15	view →
KIRP	DFS	Median	All	0.519	0.912	.002	12	view →
LIHC	OS	Median	All	0.098	0.774	.002	6	view →
PRAD	DFS	Median	All	0.617	0.886	.041	6	view →
SKCM	DFS	Median	III,IV	1.000	0.467	.027	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
UCEC	DFS	Median	All	0.931	0.628	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

GRIN2C–ACC (DFS)

Open the ACC breakdown →