Across TCGA patient cohorts, GRIN2A mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2A-associated genes across cancer lineages are ASNS, p70-S6K_pT389, and Caspase-7-cleavedD198. Each is linked with GRIN2A in more than 3 cancer types. Because this analysis shows association rather than direction, both GRIN2A-to-partner and partner-to-GRIN2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2A→partner) and Y-score (partner→GRIN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASNS →	+0.496	+3.321	.006	.011	3	4
CESC	p70-S6K_pT389 →	+0.191	+3.035	.006	.017	3	4
COAD	Caspase-7-cleavedD198 →	+0.885	+2.519	<.001	<.001	3	4
UCEC	PDCD4 →	-0.339	-1.387	.006	.001	3	4
UCEC	Cyclin-B1 →	+0.576	+2.736	<.001	<.001	3	4
LUSC	p53 →	+0.188	+1.424	.047	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Exploration

GRIN2A survival (RNA) · tumor vs normal (RNA) · all GRIN2A data types