GRIK3

Across TCGA patient cohorts, GRIK3 mutation is significantly associated with the RNA expression of many other genes, with 6,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIK3-associated genes across cancer lineages are LACTB, PCCB, and SFMBT1. Each is linked with GRIK3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIK3-to-partner and partner-to-GRIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACTB grouped by GRIK3-low versus GRIK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK3→partner) and Y-score (partner→GRIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LACTB →	+0.383	+2.970	<.001	<.001	3	5
LUAD	PCCB →	+0.494	+2.596	.002	.006	3	5
UCEC	SFMBT1 →	+0.469	+1.220	<.001	.002	3	5
COAD	PAFAH1B2 →	+0.311	+2.466	<.001	.001	3	5
UCEC	RIOK2 →	+0.421	+1.943	<.001	<.001	3	5
UCEC	TNPO1 →	+0.382	+1.728	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,481 associations by consensus.

LACTB by GRIK3 expression — UCEC

Explore this box plot interactively →