GRIK3

Across TCGA pan-cancer cohorts, GRIK3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GRIK3 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GRIK3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GRIK3 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUAD show a favorable association.

UVM, KIRP, and LUAD are the cancer types where GRIK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.780	0.433	<.001	86	view →
KIRP	DFS	Median	All	0.470	0.667	<.001	56	view →
LUAD	DFS	Median	All	0.841	0.697	<.001	54	view →
KIRC	OS	Quartile	All	0.845	0.710	<.001	54	view →
BRCA	DFS	Quartile	All	0.974	0.917	<.001	47	view →
LIHC	OS	Tertile	III,IV	0.353	0.667	.002	44	view →
READ	OS	Median	IV	0.443	0.834	.003	35	view →
ACC	DFS	Median	All	0.282	0.601	.003	26	view →
BLCA	OS	Tertile	III,IV	0.264	0.544	.004	25	view →
STAD	OS	Quartile	All	0.337	0.589	.013	15	view →
PAAD	OS	Median	All	0.689	0.536	.012	14	view →
THYM	OS	Tertile	II,III,IV	1.000	0.709	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GRIK3–UVM (OS)

Open the UVM breakdown →