GRIK3

Across TCGA patient cohorts, GRIK3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIK3-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and ASNS. Each is linked with GRIK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRIK3-to-partner and partner-to-GRIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GRIK3-low versus GRIK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK3→partner) and Y-score (partner→GRIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.622	+2.222	.010	.009	3	4
UCEC	JNK_pT183_Y185 →	-0.129	-1.362	.004	.034	3	3
COAD	ASNS →	+0.299	+1.256	.014	.028	3	3
COAD	ATM →	-0.292	-2.000	.014	.027	3	3
COAD	Caveolin-1 →	-0.643	-2.415	.003	.003	3	3
COAD	MYH11 →	-0.943	-1.874	.018	.047	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caspase-7-cleavedD198 by GRIK3 expression — COAD

Explore this box plot interactively →