GRIK3

Across TCGA cell cohorts, GRIK3 mutation is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIK3-associated genes across cancer lineages are KLHL8, TRPV1, and DDHD1. Each is linked with GRIK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIK3-to-partner and partner-to-GRIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL8 grouped by GRIK3-low versus GRIK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK3→partner) and Y-score (partner→GRIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL8 →	+0.516	+3.169	.004	.009	3	3
LARGE_INTESTINE	TRPV1 →	+0.578	+3.169	.004	.006	3	3
LARGE_INTESTINE	DDHD1 →	+0.589	+1.850	.005	.006	3	2
LARGE_INTESTINE	ACBD5 →	+0.697	+3.169	.001	.006	3	2
LARGE_INTESTINE	MCM9 →	+0.514	+1.850	.002	.006	3	2
LARGE_INTESTINE	TBCCD1 →	+0.489	+2.459	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

KLHL8 by GRIK3 expression — LARGE_INTESTINE

Explore this box plot interactively →