GRIFIN

Across TCGA patient cohorts, GRIFIN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,113 significant associations in total. STAD shows the largest number of these associations.

The most reproducible GRIFIN-associated GO terms across cancer lineages are TOR signaling, Obsolete histone methylation, and Peptidyl-lysine modification. Each is linked with GRIFIN in more than 27 cancer types. Because this analysis shows association rather than direction, both GRIFIN-to-partner and partner-to-GRIFIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOR signaling grouped by GRIFIN-low versus GRIFIN-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIFIN→partner) and Y-score (partner→GRIFIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TOR signaling →	+0.069	+0.367	<.001	<.001	3	27
STAD	Obsolete histone methylation →	+0.081	+0.363	<.001	<.001	3	27
STAD	Peptidyl-lysine modification →	+0.064	+0.386	<.001	<.001	3	27
STAD	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.077	+0.357	<.001	<.001	3	27
STAD	Positive regulation of stem cell population maintenance →	+0.065	+0.314	<.001	<.001	3	27
STAD	Protein polyubiquitination →	+0.071	+0.380	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,113 associations by consensus.

TOR signaling by GRIFIN expression — STAD

Explore this box plot interactively →