GRIFIN

Across TCGA pan-cancer cohorts, GRIFIN RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated GRIFIN data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GRIFIN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRIFIN expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

COAD, OV, and SKCM are the cancer types where GRIFIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.370	0.552	<.001	66	view →
OV	DFS	Quartile	IV	0.211	0.557	<.001	60	view →
SKCM	DFS	Quartile	II,III,IV	0.856	0.620	<.001	45	view →
UVM	DFS	Tertile	III,IV	0.399	0.789	.003	30	view →
GBM	OS	Tertile	All	0.245	0.521	.004	21	view →
CHOL	DFS	Median	II,III,IV	0.097	0.567	.006	19	view →
READ	OS	Tertile	III,IV	0.872	0.397	.004	18	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	18	view →
PRAD	DFS	Median	All	0.830	0.938	<.001	18	view →
LIHC	DFS	Tertile	II,III,IV	0.573	0.379	.008	12	view →
THCA	DFS	Tertile	IV	0.464	0.859	.032	9	view →
ACC	OS	Tertile	All	0.906	0.536	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GRIFIN–COAD (DFS)

Open the COAD breakdown →