GRIFIN

Across TCGA cell cohorts, GRIFIN RNA expression is significantly associated with the mutation status of many other genes, with 103 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GRIFIN-associated genes across cancer lineages are TRERF1, PTPN21, and ATP13A4. Each is linked with GRIFIN in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIFIN-to-partner and partner-to-GRIFIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRERF1 grouped by GRIFIN-low versus GRIFIN-high in BONE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIFIN→partner) and Y-score (partner→GRIFIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TRERF1 →	+5.169	+0.060	.004	<.001	3	2
OESOPHAGUS	PTPN21 →	+4.906	+0.080	.006	<.001	3	2
OESOPHAGUS	ATP13A4 →	+4.906	+0.080	.006	<.001	3	2
OESOPHAGUS	COPG1 →	+4.906	+0.080	.006	<.001	3	2
LUNG_SCLC	PCDHB11 →	+5.029	+0.117	.006	<.001	3	2
BLOOD_Lymphoma	NBPF14 →	+2.807	+0.037	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

TRERF1 by GRIFIN expression — BONE

Explore this box plot interactively →