GRID2

Across TCGA patient cohorts, GRID2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,009 significant associations in total. STAD shows the largest number of these associations.

The most reproducible GRID2-associated GO terms across cancer lineages are Smoothened signaling pathway, Appendage development, and Nucleobase-containing compound transport. Each is linked with GRID2 in more than 16 cancer types. Because this analysis shows association rather than direction, both GRID2-to-partner and partner-to-GRID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smoothened signaling pathway grouped by GRID2-low versus GRID2-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID2→partner) and Y-score (partner→GRID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Smoothened signaling pathway →	+0.034	+0.419	<.001	<.001	3	17
TGCT	Appendage development →	+0.042	+0.460	<.001	<.001	3	17
STAD	Nucleobase-containing compound transport →	+0.074	+0.150	<.001	<.001	3	16
STAD	Regulation of microtubule polymerization or depolymerization →	+0.041	+0.137	<.001	<.001	3	16
STAD	Regulation of microtubule polymerization →	+0.061	+0.208	<.001	<.001	3	16
ESCA	Vesicle targeting →	+0.065	+0.317	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,009 associations by consensus.

Smoothened signaling pathway by GRID2 expression — TGCT

Explore this box plot interactively →