GRID2

Across TCGA pan-cancer cohorts, GRID2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GRID2 data layer compared with 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRID2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRID2 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

UCEC, LGG, and KIRC are the cancer types where GRID2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.556	0.716	<.001	112	view →
LGG	OS	Median	All	0.513	0.340	<.001	46	view →
KIRC	OS	Median	II,III,IV	0.644	0.469	.005	41	view →
ESCA	OS	Median	IV	0.143	0.650	.004	39	view →
LIHC	OS	Tertile	All	0.344	0.619	<.001	35	view →
MESO	OS	Quartile	II,III,IV	0.250	0.517	.014	31	view →
UCS	OS	Tertile	II,III,IV	0.696	0.277	.016	28	view →
STAD	DFS	Quartile	IV	0.178	0.560	.001	28	view →
SCLC	DFS	Tertile	All	0.686	0.411	.013	23	view →
PCPG	DFS	Median	All	0.973	0.868	.003	21	view →
KIRP	OS	Tertile	II,III,IV	0.181	0.691	<.001	20	view →
THCA	OS	Quartile	III,IV	0.707	0.981	.019	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GRID2–UCEC (DFS)

Open the UCEC breakdown →