GRID2

Across TCGA patient cohorts, GRID2 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRID2-associated genes across cancer lineages are p90 RSK, HER2, and STAT3_pY705. Each is linked with GRID2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRID2-to-partner and partner-to-GRID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by GRID2-low versus GRID2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID2→partner) and Y-score (partner→GRID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.185	+1.321	<.001	.021	3	4
SKCM	HER2 →	+0.221	+1.041	.002	.009	3	4
UCEC	STAT3_pY705 →	-0.305	-1.584	<.001	.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.626	+1.912	<.001	<.001	3	3
STAD	Claudin-7 →	+0.821	+3.169	.001	.017	3	3
UCEC	ATM →	-0.484	-1.502	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

p90 RSK by GRID2 expression — SKCM

Explore this box plot interactively →