GRID2

Across TCGA cell cohorts, GRID2 mutation is significantly associated with the RNA expression of many other genes, with 742 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRID2-associated genes across cancer lineages are IL22, HM13, and CARD6. Each is linked with GRID2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRID2-to-partner and partner-to-GRID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by GRID2-low versus GRID2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID2→partner) and Y-score (partner→GRID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	2
SKIN	HM13 →	-0.524	-3.395	.001	.001	3	2
SKIN	CARD6 →	-0.960	-3.082	.001	.006	3	2
LARGE_INTESTINE	CTSS →	-2.163	-3.169	<.001	.006	3	2
LARGE_INTESTINE	KRT23 →	-3.002	-2.764	<.001	.001	3	2
LARGE_INTESTINE	DNAJC27 →	+0.419	+3.169	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

IL22 by GRID2 expression — STOMACH

Explore this box plot interactively →