GRIA4

Across TCGA patient cohorts, GRIA4 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIA4-associated genes across cancer lineages are 4E-BP1, Beclin, and Smad1. Each is linked with GRIA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIA4-to-partner and partner-to-GRIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GRIA4-low versus GRIA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA4→partner) and Y-score (partner→GRIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.340	+1.509	<.001	<.001	3	3
BLCA	Beclin →	-0.112	-2.584	.040	.010	3	3
STAD	Smad1 →	+0.173	+3.169	.003	.018	3	3
UCEC	ASNS →	+0.406	+2.000	<.001	<.001	3	3
UCEC	Chk2_pT68 →	-0.153	-1.690	.001	.001	3	3
SKCM	MEK1 →	+0.435	+2.700	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

4E-BP1 by GRIA4 expression — UCEC

Explore this box plot interactively →