GRIA4

Across TCGA cell cohorts, GRIA4 mutation is significantly associated with the RNA expression of many other genes, with 231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIA4-associated genes across cancer lineages are OR2L8, RESP18, and NPY2R. Each is linked with GRIA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIA4-to-partner and partner-to-GRIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by GRIA4-low versus GRIA4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA4→partner) and Y-score (partner→GRIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2L8 →	+0.046	+4.807	<.001	.006	3	2
OVARY	RESP18 →	+0.045	+5.196	<.001	.005	3	2
LUNG_NSCLC_LUAD	NPY2R →	+0.035	+3.043	<.001	.006	3	2
CNS	F9 →	+0.032	+4.321	<.001	.009	3	1
CNS	DBX1 →	+0.615	+4.315	<.001	.006	3	1
CNS	ZNF705G →	+0.011	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 231 associations by consensus.

OR2L8 by GRIA4 expression — BLOOD_Myeloma

Explore this box plot interactively →