GRIA4

Across TCGA cell cohorts, GRIA4 mutation is significantly associated with the mutation status of many other genes, with 5,084 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIA4-associated genes across cancer lineages are NUP210, OGT, and KMT2A. Each is linked with GRIA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both GRIA4-to-partner and partner-to-GRIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP210 grouped by GRIA4-low versus GRIA4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA4→partner) and Y-score (partner→GRIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NUP210 →	+2.548	+2.641	.008	.008	1	6
BLOOD_Lymphoma	OGT →	+5.247	+4.429	.005	.005	1	6
UPPER_AERODIGESTIVE_TRACT	KMT2A →	+4.193	+4.193	.002	.002	1	6
BLOOD_Lymphoma	HCN1 →	+3.025	+3.754	.006	.006	1	5
STOMACH	KIDINS220 →	+3.584	+3.584	.006	.006	1	5
LARGE_INTESTINE	EMSY →	+3.857	+2.807	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,084 associations by consensus.

NUP210 by GRIA4 expression — SKIN

Explore this box plot interactively →