GRIA1

Across TCGA patient cohorts, GRIA1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIA1-associated genes across cancer lineages are MIG-6, INPP4B, and 4E-BP1. Each is linked with GRIA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIA1-to-partner and partner-to-GRIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by GRIA1-low versus GRIA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA1→partner) and Y-score (partner→GRIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.118	+2.451	<.001	<.001	3	5
BRCA	INPP4B →	-0.683	-3.000	.024	.037	3	3
UCEC	4E-BP1 →	+0.184	+2.584	.033	.010	3	3
BLCA	STAT5a →	-0.494	-3.000	.031	.034	3	2
BLCA	YAP →	+0.332	+3.321	<.001	.010	3	2
BLCA	14-3-3_zeta →	+0.301	+3.321	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

MIG-6 by GRIA1 expression — COAD

Explore this box plot interactively →