GRIA1

Across TCGA pan-cancer cohorts, GRIA1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GRIA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GRIA1 RNA is repressed in tumor relative to normal tissue. In most cancer types GRIA1 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and THCA are the cancer types where GRIA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−3.098	<.001	11	view →
BLCA	Male	III,IV	−0.264	<.001	11	view →
THCA	Female	II,III,IV	−0.279	<.001	10	view →
COAD	Female	II,III,IV	−0.211	<.001	10	view →
LUSC	Female	II,III,IV	−3.144	<.001	9	view →
HNSC	All	All	−0.114	.005	7	view →
BRCA	All	All	−0.634	<.001	4	view →
STAD	All	All	−0.206	.021	3	view →
UCEC	All	All	−0.408	<.001	2	view →
PRAD	All	All	−0.060	<.001	2	view →
KIRP	All	All	−0.055	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GRIA1–LUAD

Open the LUAD breakdown →